Modelling suggests ABO histo-incompatibility may substantially reduce SARS-CoV-2 transmission

• Modelling suggests that blood type incompatibility may reduce the chance of transmitting SARS-CoV-2 by 60 % or more. Type O individuals are less likely to be infected, but “universal donors” and more spread infection. The risk A B depends upon which is frequent in population. Blood group frequencies partly explain different epidemic severity regions world. It important for ALL types vaccinated rather than targeting any specific group. Several independent datasets suggest over-represented under-represented among COVID-19 patients. However, antigens appear not conventional susceptibility factors they do affect disease severity, relative non-O attenuated when population prevalence high. Here, I model a scenario ABO transfusion reduces patient virus an incompatible recipient – thus Western populations AB “super-recipients” while “super-spreaders”. This results offset timing types, increased A/AB patients most pronounced during early stages epidemic. once majority given each approaches unity. Published data on from if this holds true, transmissibility at least %. Exploring implications vaccination strategies shows paradoxically, targeted either high-susceptibility “super-spreader” effective random blocking community virus. Instead, key maintain diversity remaining susceptible individuals. Given good agreement between observational prevalence, underlying biochemistry urgently requires experimental investigation.